J. Brent Friesen Publications

2021

P Achanta, B Jaki, J McAlpine, JB Friesen, M Niemitz, SN Chen, G Pauli 

Quantum Mechanical NMR Full Spin Analysis in Pharmaceutical Identity Testing and Quality Control 

Journal of Pharmaceutical and Biomedical Analysis, 195, 113601 (2021) 

10.1016/j.jpba.2020.113601

publication

publication 

publication 

2020

SB Kim, J Bisson, JB Friesen, G Pauli, C Simmler
Selective Chlorophyll Removal Method to “Degreen” Botanical Extracts
Journal of Natural Products 83, 1846–1858 (2020)
dx.doi.org/10.1021/acs.jnatprod.0c00005

S AbouZid, H Ahmed, AE Abd El Mageed, A Moawad, A Owis, SN Chen, A Nachtergael, J McAlpine, J Friesen, G Pauli
Linear regression analysis of silychristin A, silybin A and silybin B contents in Silybum marianum
Natural Product Research 34, 305-310 (2020)
dx.doi.org/10.1080/14786419.2018.1527838

 

K Nelson, J Bisson, G. Singh, J Graham, S-N Chen, JB Friesen, J Dahlin, M Niemitz, M Walters, G Pauli 

The Essential Medicinal Chemistry of Cannabidiol (CBD) 

Journal of Medicinal Chemistry 63, 12137-12155 (2020) 

10.1021/acs.jmedchem.0c00724

 

T Yu, JB Friesen, DC. Lankin, JB McAlpine, DS Nikolić, M Niemitz, DS. Seigler, JG. Graham, S-N Chen, and GF Pauli, 

Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides from Rhodiola rosea. 

Journal of Natural Products 83, 1950-1959 (2020) 

10.1021/acs.jnatprod.0c00212

 

2019

K Duric, Y Liu, S-N Chen, D Lankin, D Nikolic, J McAlpine, JB Friesen, G Pauli
Studying Mass Balance and the Stability of (Z)-Ligustilide from Angelica sinensis Helps to Bridge a Botanical Instability-Bioactivity Chasm
Journal of Natural Products 82, 2400-2408 (2019)
dx.doi.org/10.1021/acs.jnatprod.8b00962

G Malca, JB Friesen, Y Liu, D Nikolic, D Lankin, J McAlpine, SN Chen, G Pauli
Preparation of DESIGNER extracts of red clover (Trifolium pratense L.) by centrifugal partition chromatography
Journal of Chromatography A 1606, 360277 (2019)
dx.doi.org/10.1016/j.chroma.2019.05.057

G Malca, D Zagal, J Graham, D Nikolic, JB Friesen, D Lankin, SN Chen, G Pauli
Dynamics of the isoflavone metabolome of traditional preparations of Trifolium pratense L.
Journal of Ethnopharmacology 111865 (2019)
dx.doi.org/10.1016/j.jep.2019.111865

Y Chen, X Yan, F Lu, X Jian, JB Friesen, G Pauli, SN Chen, D Li
Preparation of flavone di-C-glycoside isomers from Jian-Gu Injection (Premna fulva Craib.) using recycling counter-current chromatography
Journal of Chromatography A 1599, 180-186 (2019)
dx.doi.org/10.1016/j.chroma.2019.03.030

JB Friesen, Y Liu, SN Chen, J McAlpine, G Pauli
Selective Depletion and Enrichment of Constituents in “Curcumin” and Other Curcuma longa Preparations
Journal of Natural Products, 82, 621-630 (2019)
dx.doi.org/10.1021/acs.jnatprod.9b000020 

 

2018

Y Liu, JB Friesen, J McAlpine, D Lankin, SN Chen, G Pauli
Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives
Journal of Natural Products, 2018, 81, 679-690 
dx.doi.org/10.1021/acs.jnatprod.7b00945

Q Fan, Y Liu, D Kulakowski, SN Chen, JB Friesen, G Pauli, Q Song
Countercurrent separation assisted identification of two mammalian steroid hormones in Vitex negundo
Journal of Chromatography A, 1553, 108-115 (2018)
dx.doi.org/10.1016/j.chroma.2018.04.033

Y Liu, Y Zhang, SN Chen, JB Friesen, D Nikolic, M Choules, J McAlpine, D Lankin, R Gemeinhart, G Pauli
The Influence of Natural Deep Eutectic Solvents on Bioactive Natural Products: Studying Interactions between a Hydrogel Model and Schisandra chinensis Metabolites
Fitoterapia, 2018 129, 212-219
dx.doi.org/10.1016/j.fitote.2018.02.024

 

2017

Friesen, J.B.; McAlpine, J.; Chen, S-N.; Pauli, G. 

The 9th International Countercurrent Chromatography Conference Held at Dominican University, Chicago, USA, August 1-3, 2016. 

Journal of Chromatography A, 2017, 1520, 1-8 

10.1016/j.chroma.2017.08.077

 

AbouZid, S.F.; Ahmed, H.; Moawad, A.;  Owis, A.;  Chen, S-N.; Nachtergael, A.; McAlpine, J.;  Friesen, J.B.;G Pauli, G. 

Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations. 

Fitoterpia 2017, 119, 175-184  

10.1016/j.fitote.2017.04.002

 

Yang Liu, J. Brent Friesen, Edyta M. Grzelak, Qingfei Fan, Ting Tang, Kemal Durić, Birgit U. Jaki, James B. McAlpine, Scott G. Franzblau, Shao-Nong Chen, Guido F. Pauli. 

Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy 

Journal of Chromatography A 2017, 1054, 46–54 

10.1016/j.chroma.2017.04.055

 

2016

AbouZida, S. F.; Chen, S.-N.; McAlpine, J. B.; Friesen, J. B.; Guido F. Pauli, G. F. 

Silybum marianum pericarp yields enhanced silymarin products 

Fitoterapia 2016, 112, 136-143 

10.1016/j.fitote.2016.05.012

 

J. Bisson, C. Simmler, S.-N. Chen, J.B. Friesen, D. Lankin, J. McAlpine, G. Pauli. 

Dissemination of Original NMR Data Enhances Reproducibility and Integrity in Chemical Research. 

Natural Product Reports 2016, 33, 1028-1033 

10.1039/c6np00022c

 

Y. Liu, J. Garzon, J.B. Friesen, Y. Zhang, J. McAlpine, D. Lankin, S.-N. Chen, G. Pauli. 

Countercurrent Assisted Quantitative Recovery of Metabolites from Plant-Associated Natural Deep Eutectic Solvents. 

Fitoterapia 2016, 122: 30-37 

10.1016/j.fitote.2016.04.019

 

Bisson, J., McAlpine, J, Friesen, J. B., Chen, S-N., Graham, J., Pauli, G. F. 

Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery? 

Journal of Medicinal Chemistry 2016, 59: 1671-1690.

10.1021/acs.jmedchem.5b01009

 

Pauli, G. F., Niemitz, M., Bisson, J., Lodewyk, M. W., Soldi, C., Shaw, J. T., Tantillo, D. J., Saya, J. M., Vos, K., Kleinnijenhuis, R. A., Hiemstra, H., Chen, S.-N., McAlpine, J. B., Lankin, D. Friesen, J. B. 

Toward Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving. 

Journal of Organic Chemistry 2016, 81, 878-889.

10.1021/acs.joc.5b02456

 

2015

Liu, Y.; Friesen, J. B.; Klein, L. L.; McAlpine, J. B.; Lankin, D. C.; Pauli, G. F.; Chen, S.-N., 

The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent separation. 

Journal of Chromatography A 2015, 1426, 248-251. 

10.1021/acs.analchem.5b01613

 

Liu, Y.; Friesen, J. B.; McAlpine, J. B.; Pauli, G. F., 

Solvent System Selection Strategies in Countercurrent Separation. 

Planta Medica 2015, 18, 1582-1591. 

10.1055/s-0035-1546246

 

Pauli, G. F.; Pro, S. M.; Chadwick, L. R.; Burdick, T.; Pro, L.; Friedl, W.; Novak, N.; Maltby, J.; Qiu, F.; Friesen, J. B.,

Real-Time Volumetric Phase Monitoring: Advancing Chemical Analysis by Countercurrent Separation. 

Analytical Chemistry 2015, 87, 7418-7425. 

10.1021/acs.analchem.5b01613

 

Friesen, J. B.; McAlpine, J. B.; Chen, S.-N.; Pauli, G. F., 

Countercurrent Separation of Natural Products: An Update. 

Journal of Natural Products 2015, 78, 1765-1796. 

https://doi.org/10.1021/np501065h

 

Friesen, J. B.; Ahmed, S.; Pauli, G. F., 

Qualitative and quantitative evaluation of solvent systems for countercurrent separation.

Journal of Chromatography A 2015, 1377, 55-63.

10.1016/j.chroma.2014.11.085

Friesen, J. B., 

Activities Designed for Fingerprint Dusting and the Chemical Revelation of Latent Fingerprints. 

10.1021/ed500406v

 

Friesen, J. B., 

Forensic Chemistry: The Revelation of Latent Fingerprints. 

Journal of Chemical Education 2015, 92, 497-504.

10.1021/ed400597u


2014

Pauli, G. F.; Chen, S. N.; Simmler, C.; Lankin, D. C.; Godecke, T.; Jaki, B. U.; Friesen, J. B.; McAlpine, J. B.; Napoitano, J. G., 

Importance of Purity Evaluation and the Potential of Quantitative H-1 NMR as a Purity Assay. 

Journal of Medicinal Chemistry 2014, 57, 9220-9231

Simmler, C.; Nikolic, D.; Lankin, D. C.; Yu, Y.; Friesen, J. B.; van Breemen, R. B.; Lecomte, A.; Le Quemener, C.; Audo, G.; Pauli, G. F., 

Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice. 

Journal of Natural Products 2014, 77, 1806-1816.

Ramos Alvarenga, R. F.; Friesen, J. B.; Nikolic, D.; Simmler, C.; Napolitano, J. G.; vanBreemen, R.; Lankin, D. C.; McAlpine, J. B.; Pauli, G. F.; Chen, S. N., 

K-Targeted Metabolomic Analysis Extends Chemical Subtraction to DESIGNER Extracts: Selective Depletion of Extracts of Hops (Humulus lupulus). 

Journal of Natural Products 2014, 77, 2595-2604.

Liu, Y.; Chen, S. N.; McAlpine, J. B.; Klein, L. L.; Friesen, J. B.; Lankin, D. C.; Pauli, G. F., 

Quantification of a Botanical Negative Marker without an Identical Standard: Ginkgotoxin in Ginkgo biloba. 

Journal of Natural Products 2014, 77, 611-617.

2013

Napolitano, J. G.; Lankin, D. C.; Graf, T. N.; Friesen, J. B.; Chen, S. N.; McAlpine, J. B.; Oberlies, N. H.; Pauli, G. F., 

HiFSA Fingerprinting Applied to Isomers with Near-Identical NMR Spectra: The Silybin/Isosilybin Case. 

Journal of Organic Chemistry 2013, 78, 2827-2839.

2012

Qiu, F.; Friesen, J. B.; McAlpine, J. B.; Pauli, G. F., 

Design of countercurrent separation of Ginkgo biloba terpene lactones by nuclear magnetic resonance. 

Journal of Chromatography A 2012, 1242, 26-34.

Pauli, G. F.; Chen, S. N.; Friesen, J. B.; McAlpine, J. B.; Jaki, B. U., 

Analysis and purification of bioactive natural products: the AnaPurNa study. 

Journal of Natural Products 2012, 75, 1243-55.

2011

Friesen, J. B.; Schretzman, R., 

Dehydration of 2-Methyl-1-cyclohexanol: New Findings from a Popular Undergraduate Laboratory Experiment. 

Journal of Chemical Education 2011, 88, 1141-1147.

Chen, S. N.; Friesen, J. B.; Webster, D.; Nikolic, D.; van Breemen, R. B.; Wang, Z. J.; Fong, H. H. S.; Farnsworth, N. R.; Pauli, G. F., 

Phytoconstituents from Vitex agnus-castus fruits. 

Fitoterapia 2011, 82, 528-533.

2010

Pauli, G. F.; Friesen, J. B.; Godecke, T.; Farnsworth, N. R.; Glodny, B., 

Occurrence of Progesterone and Related Animal Steroids in Two Higher Plant. 

Journal of Natural Products 2010, 73, 338-345.

2009

Friesen, J. B.; Pauli, G. F., 

Binary concepts and standardization in counter-current separation technology. 

Journal of Chromatography A 2009, 1216, 4237-4244.

Friesen, J. B.; Pauli, G. F., 

GUESSmix-guided optimization of elution-extrusion counter-current separations. 

Journal of Chromatography A 2009, 1216, 4225-4231.

2008

Pauli, G. F.; Pro, S. M.; Friesen, J. B., 

Countercurrent separation of natural products.

Journal of Natural Products 2008, 71, 1489-1508.

Friesen, J. B.; Pauli, G. F., 

Performance characteristics of countercurrent separation in analysis of natural products of agricultural significance. 

Journal of Agricultural and Food Chemistry 2008, 56, 19-28.

Friesen, J. B., Saying What You Mean: Teaching Mechanisms in Organic Chemistry. 

Journal of Chemical Education 2008, 85, 1515-1518.

Chen, S. N.; Turner, A.; Jaki, B. U.; Nikolic, D.; van Breemen, R. B.; Friesen, J. B.; Pauli, G. F., 

An Experimental Implementation of Chemical Subtraction. 

Journal Pharmaceutical and Biomedical Analysis 2008, 46, 692-698.

2007

 Friesen, J. B.; Pauli, G. F., 

Rational development of solvent system families in counter-current chromatography. 

Journal of Chromatography A 2007, 1151, 51-59.

Friesen, J. B.; Pauli, G. F., 

Reciprocal symmetry plots as a representation of countercurrent chromatograms. 

Analytical Chemistry 2007, 79, 2320-2324.

Berthod, A.; Friesen, J. B.; Inui, T.; Pauli, G. F., 

Elution-extrusion countercurrent chromatography: Theory and concepts in metabolic analysis. 

Analytical Chemistry 2007, 79, 3371-3382.

2005

Friesen, J. B.; Pauli, G. F., 

GUESS – A generally useful estimate of solvent systems in CCC. 

Journal of Liquid Chromatography and Related Technologies 2005, 28, 2777-2806.

1992

Friesen, J. B.; Burkhouse, P. C.; Biesboer, D. D.; Leete, E., 

Biosynthesis of the Tobacco Alkaloids and Related Compounds .54. Influence of Alkaloid Precursors on the Alkaloid Content of Nicotiana Alata Root Cultures. 

Phytochemistry 1992, 31, 3059-3063.

1991

Couladis, M. M.; Friesen, J. B.; Landgrebe, M. E.; Leete, E., 

Chemistry of the Tropane Alkaloids and Related-Compounds .47. Enzymes Catalyzing the Reduction of Tropinone to Tropine and PseudoTropine Isolated from the Roots of Datura Innoxia. 

Phytochemistry 1991, 30, 801-805.

1990

Friesen, J. B.; Leete, E., 

Biosynthesis of the Tobacco Alkaloids and Related-Compounds .52. Nicotine Synthase – an Enzyme from Nicotiana Species Which Catalyzes the Formation of (S)-Nicotine from Nicotinic-Acid and 1-Methyl-D’-Pyrrolinium Chloride. 

Tetrahedron Letters 1990, 31, 6295-6298.